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By Thomas Harry Sharp

As a part of a collaboration among varied teams in chemistry and biochemistry, Thom Sharp offers the following his thesis paintings at the improvement of latest equipment for cryoelectron microscopy. all through his Ph.D., Thom needed to grasp an entire variety of strategies together with modelling, molecular biology and microscopy. utilizing those talents to take on an exceptional challenge, the pursuit of high-resolution constructions of peptide-based fabrics, Thom highlights during this thesis his newly constructed equipment for analysing and processing this actual kind of electron microscopy facts. This thesis provides the 1st molecular description of a de-novo designed peptide-based fabric. normally, this study can have a huge effect at the peptide meeting box, and likewise in electron microscopy because it introduces new tools and methods, all of that are Thom's innovations and are defined during this thesis.

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